Marine sponge compounds with antiplasmodial properties: Focus on in vitro study against Plasmodium falciparum

doi:10.7324/japs.2020.10519

Abstract

Highlights

Malaria is the most life-threatening and infectious disease caused by Plasmodium parasites such as Plasmodium falciparum, Plasmodium ovale, Plasmodium vivax, Plasmodium malariae
The molecules were classified into potent, good, moderate, low, and inactive based on their IC50, and among observed bioactive metabolites, there were 57 marine sponge molecules reported to act as potent antiplasmodium against various strains of P. falciparum including drug resistance and nondrug resistance
The class of the listed compounds includes manzamine alkaloid, guanidine alkaloids, bispyrroloiminoquinone alkaloids, pyrroloiminoquinone alkaloids, ingamine alkaloids, bromotyrosine alkaloids, sesquiterpenoids, diterpene formamides, aminoimidazole, β-galactosylceramides, β-lactam, meroterpene, trisoxazole macrolides, peroxides, thiazine alkaloids, and sterols. With this up-to-date review, we attempt to present new perspectives for the rational discovery of novel sponge metabolites that can be used as lead compounds in antimalarial drug development

Summary

Introduction

Malaria is the most life-threatening and infectious disease caused by Plasmodium parasites such as Plasmodium falciparum, Plasmodium ovale, Plasmodium vivax, Plasmodium malariae. Among those protozoans, P. falciparum is considered to be responsible for most severe diseases and most fatal cases. Malaria continues to be a major cause of morbidity and mortality in tropical countries. It is further aggravated by an increase in a number of multidrug-resistant strains of Plasmodium accompanied by a lack of progress in the development of vaccines and drug discovery. The search of new agent that actives against malaria becomes urgent needs (Antony and Parija 2016; Burrows et al, 2011; Cui et al, 2015; Dondorp et al, 2000; Noedl et al, 2008)

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