Abstract
The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine “cell factories” for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of Alexandrium tamarensis WE, Gambierdiscus australes, Prorocentrum arenarium, Prorocentrum hoffmannianum, and Prorocentrum reticulatum (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae.
Highlights
We are in a renaissance period for natural product discovery and their potential societal impact as a source of therapeutic drugs is popular [1]
The crude extracts from biomass and cell free culture medium were obtained by maceration/sonication in methanol and by using a solid phase extraction (SPE) on Diaion
The non-neurotoxic dinoflagellates as which are responsible of causing growth paralytic shellfish poisoning (PSP). the the nonof saxitoxins, this genus can suppress copepod population. These findings indicate importance of neurotoxic of the thistoxin genusprofile can suppress copepod population growthsearching
Summary
We are in a renaissance period for natural product discovery and their potential societal impact as a source of therapeutic drugs is popular [1]. An exciting field of activity is the development of therapeutics from the marine ecosystem in which the discovery of novel drugs, to date, is small compared to its potential [2,3,4]. The outlook for blue biotechnology has changed profoundly over the last decade in large part due to advances in science and technology. This topic encompasses techniques such as bioprocessing, bio-harvesting, bioprospecting, bioremediation, molecular aquaculture, omics approaches, etc., which comprises a horizontal scope and a broad range of subjects [10,11]. A major task of marine biotechnology is to develop an efficient process for the discovery of new and more effective drugs
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