Abstract
BackgroundWound complications are a major source of morbidity after cesarean section (CS) and contribute to increased risks in subsequent pregnancies. In the present study, we aim to investigate the wound healing potential of a kind of oligopeptide compound, mainly derived from the marine fish peptides (MFPs), in rats after CS by biomechanical, biochemical, and histological methods.MethodsEighty-four pregnant Sprague–Dawleyrats were randomly assigned to four groups, namely the control group and 1.1, 2.2, and 4.4 mg/kg MFP groups, respectively. The MFPs or normal saline of the equal volume was intragastrically administered every morning on the second day after CS. On days 5, 10, and 15 after the surgery, seven rats from each group were randomly selected. The samples of skin wound and uterus were harvested and then used for the following experiments and analyses.ResultsUsing the CS rat model, this study demonstrated that in the MFP groups, the skin tensile strength, uterine bursting pressure, and hydroxyproline (Hyp) were significantly higher than those in the control group at all three time points (P < 0.05). The formation of collagen and smooth muscle fibers and the expression of CD34 and connective tissue growth factor at the incision site were increasingly observed in the MFP groups (P < 0.05).ConclusionsMFPs have a great potential to accelerate the process and quality of wound healing in rats after CS.
Highlights
Wound complications are a major source of morbidity after cesarean section (CS) and contribute to increased risks in subsequent pregnancies
Using the CS rat model, this study demonstrated that in the marine fish peptides (MFPs) groups, the skin tensile strength, uterine bursting pressure, and hydroxyproline (Hyp) were significantly higher than those in the control group at all three time points (P < 0.05)
MFPs accelerated collagen and smooth muscle proliferation and maturation process in wounds We identified the site of prior uterine CS surgery in the control group and 1.1, 2.2, and 4.4 mg/kg MFP groups at days 5, 10, and 15, respectively
Summary
Wound complications are a major source of morbidity after cesarean section (CS) and contribute to increased risks in subsequent pregnancies. We aim to investigate the wound healing potential of a kind of oligopeptide compound, mainly derived from the marine fish peptides (MFPs), in rats after CS by biomechanical, biochemical, and histological methods. Methods: Eighty-four pregnant Sprague–Dawleyrats were randomly assigned to four groups, namely the control group and 1.1, 2.2, and 4.4 mg/kg MFP groups, respectively. On days 5, 10, and 15 after the surgery, seven rats from each group were randomly selected. Results: Using the CS rat model, this study demonstrated that in the MFP groups, the skin tensile strength, uterine bursting pressure, and hydroxyproline (Hyp) were significantly higher than those in the control group at all three time points (P < 0.05).
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