Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration.

Sarah Geahchan,Parnian Baharlouei,Azizur Rahman

doi:10.3390/md20010061

Abstract

Marine organisms harbor numerous bioactive substances that can be utilized in the pharmaceutical and cosmetic industries. Scientific research on various applications of collagen extracted from these organisms has become increasingly prevalent. Marine collagen can be used as a biomaterial because it is water soluble, metabolically compatible, and highly accessible. Upon review of the literature, it is evident that marine collagen is a versatile compound capable of healing skin injuries of varying severity, as well as delaying the natural human aging process. From in vitro to in vivo experiments, collagen has demonstrated its ability to invoke keratinocyte and fibroblast migration as well as vascularization of the skin. Additionally, marine collagen and derivatives have proven beneficial and useful for both osteoporosis and osteoarthritis prevention and treatment. Other bone-related diseases may also be targeted by collagen, as it is capable of increasing bone mineral density, mineral deposition, and importantly, osteoblast maturation and proliferation. In this review, we demonstrate the advantages of marine collagen over land animal sources and the biomedical applications of marine collagen related to bone and skin damage. Finally, some limitations of marine collagen are briefly discussed.

Highlights

The extracellular matrix (ECM) plays important roles in the physical integrity of cells, where it is involved in cell proliferation, differentiation, migration, and adhesion [1,2,3,4,5,6].Collagen is the main structural protein in the ECM and connective tissue of animals
Not vascularization at days post-treatment. These results are similar to the experiment surprisingly, rats in the collagen-treated group showed elevated fibroblast proliferation of Zhang et al, whoatdemonstrated that marine collagen peptides wound closure and vascularization
Melotti et al manufactured collagenbased skin-like scaffolds (CBSSs) from collagen isolated from sea urchin food waste to treat skin wounds in sheep [69]

Summary

Introduction

The extracellular matrix (ECM) plays important roles in the physical integrity of cells, where it is involved in cell proliferation, differentiation, migration, and adhesion [1,2,3,4,5,6]. Marine harbo significant source of collagen and are highly advantageous over other sources, collagen isolated from organisms like fish, jellyfish, and sponges has been implicated in as they metabolically compatible, lack religious constraints and are free of animal pathogens [2 several studies on its potential for increasing wound healing rates [36,37,38,39,40,41]. Example, cattle, a la Studies on humans have shown that marine collagen can reduce wrinkles, improve source of collagen, pose risks for bovine spongiform encephalopathy (BSE) as well skin elasticity, andtransmissible enhance thespongiform overall structure and appearance of skin. Some limitations associated with the use of marine collagen exist, it is evident that the advantageous and efficacious potential of marine collagen significantly outweighs its drawbacks

Collagen

The 3D and innerstructure collagen structure

Histologic

Advantages and Limitations

Findings

Concluding Remarks