Abstract
Oxidative stress induced by reactive oxygen species plays an important role in the etiology of many diseases. Dietary phytochemical products, such as bioactive food components and marine carotenoids (asthaxantin, lutein, β-carotene, fucoxanthin), have shown an antioxidant effect in reducing oxidative markers stress. Scientific evidence supports the beneficial role of phytochemicals in the prevention of some chronic diseases. Many carotenoids with high antioxidant properties have shown a reduction in disease risk both in epidemiological studies and supplementation human trials. However, controlled clinical trials and dietary intervention studies using well-defined subjects population have not provided clear evidence of these substances in the prevention of diseases. The most important aspects of this special issue will cover the synthesis, biological activities, and clinical applications of marine carotenoids, with particular attention to recent evidence regarding anti-oxidant and anti-inflammatory properties in the prevention of cardiovascular disease.
Highlights
Oxidative stress (OS) and chronic inflammation are the major pathophysiological factors contributing to the development of cardiovascular diseases (CVD), such as hypertension, diabetes and atherosclerosis
Advances in pathophysiological research suggest that CVD represent a continuum of pathophysiological processes that advance from local redox imbalance to endothelial dysfunction, endothelial inflammation, and excessive vascular remodeling
Consequent cell damage contributes to atherosclerosis, coronary artery disease (CAD), stroke and myocardial infarction [5,6]
Summary
Oxidative stress (OS) and chronic inflammation are the major pathophysiological factors contributing to the development of cardiovascular diseases (CVD), such as hypertension, diabetes and atherosclerosis. Abstract: Oxidative stress induced by reactive oxygen species plays an important role in the etiology of many diseases. Dietary phytochemical products, such as bioactive food components and marine carotenoids (asthaxantin, lutein, β-carotene, fucoxanthin), have shown an antioxidant effect in reducing oxidative markers stress.
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