Abstract
Marine biotechnology: diving deeper for drugs.
Highlights
‘That which does not kill us, makes us stronger’ was Friedrich Nietzsche’s quote in his Twilight of the Idols
A promising strategy to re-tap the reservoir of natural antibiotics is to shift focus from the terrestrial to the marine environment, which is despite a growing number of studies still largely mare incognita
It has been said that we know more about the surface of the Moon than about the bottom of our oceans (Snelgrove, 2011), but we do not need to go very deep for us to be rather ignorant about the biology and the molecules that can be found
Summary
‘That which does not kill us, makes us stronger’ was Friedrich Nietzsche’s quote in his Twilight of the Idols. Development of new antibiotic scaffolds is not the only intervention needed, it is crucial to find novel ‘last resort’ antibiotics to treat patients infected with multidrugresistant bacteria. The quest for new molecules with pharmaceutical properties has seen a shift away from large synthetic combinatorial libraries and a return to nature during the last decade.
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