Marginal involvement after large loop excision of transformation zone in patients with cervical cancerous lesion

Abstract

When patients exhibited involvement of the margin after LLETZ some authors insisted that an involved margin after conization usually indicates the presence of residual disease and warrants further management such as immediate second LLETZ or even hysterectomy. However there were some opinions that expectant management is reasonable for patients with CIN III and positive margins after cold-knife conization is reasonable with careful follow-up. The purpose of this study was to analyze retrospectively the methods of management utilized in cases of margin involvement after LLETZ in patients with CIN III and microinvasive squamous cell carcinoma of the uterine cervix (MSC). A retrospective analysis was performed on all clinicopathologic records for the 2341 patients who underwent outpatient LLETZ for the cervical lesions diagnosed as CIN I—III or MSC by punch biopsy. (excerpt)