Abstract
Inflammation is an essential action to protect the host human body from external, harmful antigens and microorganisms. However, an excessive inflammation reaction sometimes exceeds tissue damage and can disrupt organ functions. Therefore, anti-inflammatory action and resolution mechanisms need to be clarified. Dietary foods are an essential daily lifestyle that influences various human physiological processes and pathological conditions. Especially, omega-3 fatty acids in the diet ameliorate chronic inflammatory skin diseases. Recent studies have identified that omega-3 fatty acid derivatives, such as the resolvin series, showed strong anti-inflammatory actions in various inflammatory diseases. Maresin-1 is a derivative of one of the representative omega-3 fatty acids, i.e., docosahexaenoic acid (DHA), and has shown beneficial action in inflammatory disease models. In this review, we summarize the detailed actions of maresin-1 in immune cells and inflammatory diseases.
Highlights
The human body is exposed to various environmental stimuli which drive appropriate host defense reactions to protect against harmful antigens and/or microorganisms [1].On the one hand, inflammatory responses are essential to drive host defense actions and the remodeling of organ tissues [2]
Maresin-1 was first identified in human macrophages and was shown to be a lipid mediator that was active in the process of inflammatory resolution
Oral intake of docosahexaenoic acid (DHA) has been shown to impair disease activity in an animal model of Alzheimer’s disease [33]. These findings suggest that maresin-1, which is a derivative of DHA, should show therapeutic efficacy against
Summary
The human body is exposed to various environmental stimuli which drive appropriate host defense reactions to protect against harmful antigens and/or microorganisms [1]. Inflammatory responses are essential to drive host defense actions and the remodeling of organ tissues [2]. Because inflammation has been implicated in many human diseases, anti-inflammatory agents should be applied to various inflammatory diseases. Among the various nutritional factors, fatty acids are components of cell membranes that regulate cellular signal transduction [4,5]. Lipid mediator metabolites derived from omega-3 fatty acids act on various physiological processes or pathological conditions by regulating lipid metabolism, cell signaling, and inflammation [8,9,10,11]. Maresin-1 is one of the highlighted metabolites from eicosapentaenoic acid (EPA) that shows various strong anti-inflammatory actions in inflammatory diseases. We summarize the actual impacts of maresin-1 on various diseases and discuss the detailed molecular mechanisms of maresin-1 focusing on its anti-inflammatory action
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
