Marchiafava-Bignami Disease Associated with Spinal Involvement.

Jhon Perea,Horacio Solarz,Luciana Grimanesa Lázaro,José Crespo,Sergio Scollo,María Belén Luis,Agustina Tamargo,Nora Fernández Liguori,Ricardo Alonso,Maira Avalle,Mehmet Turgut

doi:10.1155/2020/8867383

Abstract

Marchiafava–Bignami disease (MBD) is a rare disorder of unknown etiology, strongly associated with alcoholism and malnutrition. MBD causes primary involvement of the corpus callosum, leading to confusion, dysarthria, seizures, and frequent death. We report the case of a 54-year-old male without a history of alcoholism or known malabsorption disease, who presented with altered consciousness and neurologic impairment. Complex B deficiency was addressed. Magnetic resonance imaging (MRI) showed typical corpus callosum lesions. The clinical features and radiologic images suggested spinal cord involvement. Brain histopathologic findings were consistent with MBD. Despite vitamin replacement therapy, he had a poor outcome.

Highlights

Marchiafava–Bignami Disease (MBD) is a rare disorder that affects adults between 40 to 60 years of age, with a male predominance, and a history of chronic alcoholism and/or malnutrition. It has been associated with vitamin B complex deficiency, and its main feature is progressive demyelination and necrosis of the corpus callosum [1]. ere is involvement of other cerebral structures, such as hemispheric white matter, middle cerebellar peduncle, and basal ganglia
We present the case of a 54-year-old man suffering from vitamin B complex deficiency and spinal cord involvement, with histopathologic examination consistent with MBD
This affection was found in people with severe nutritional deficits [14]. It has been associated with vitamin B complex deficiency, primarily thiamine deficiency

Summary

Introduction

Marchiafava–Bignami Disease (MBD) is a rare disorder that affects adults between 40 to 60 years of age, with a male predominance, and a history of chronic alcoholism and/or malnutrition. It has been associated with vitamin B complex deficiency, and its main feature is progressive demyelination and necrosis of the corpus callosum [1]. Few cases of spinal cord involvement were reported [2, 3]. We present the case of a 54-year-old man suffering from vitamin B complex deficiency and spinal cord involvement, with histopathologic examination consistent with MBD

Case Report

Discussion

Findings

Conclusion