Abstract
Marchiafava-Bignami disease (MBD) is a very rare disorder of demyelination/necrosis of the corpus callosum and the near subcortical white matter that is especially predominant in illfed alcoholics. The disease can be acute, subacute, or chronic. The clinical picture is marked by dementia, dysarthria, spasticity, and walking inability. It is a very rare condition. In the United States, one study found 250 published cases were reported before 2001, suggesting it is likely many cases have gone undiagnosed. International data is similar, always reminding that the prevalence is underestimated because of the non-autopsied patients. Published in approximately 300 case reports.
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