Abstract
Marchiafava-Bignami disease (MBD) is a rare demyelinating and necrotic disorder of the corpus callosum, classically presenting with altered mental status. Increasing evidence shows that lesions can localize also in the subcortical white matter, presenting with focal symptoms and carrying a poorer prognosis. We describe the clinical and radiological findings of a patient with MBD presenting as mixed transcortical aphasia (MTA), remarkably improving after thiamine treatment.
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