Abstract
Abstract Introduction: Marchiafava-Bignami disease (MBD) is a rare outcome often associated with chronic alcohol abuse. Clinical manifestations are diverse. Recently, brain magnetic resonance imaging has paved the way for the diagnosis of MBD. Patient concerns: A 62-year-old man was admitted to our hospital because of headache and mild cognitive impairment. He had an alcohol consumption (500 g/d) history for over 20 years. Diagnosis: Based on Magnetic Resonance Imaging, he was diagnosed with Marchiafava-Bignami disease (MBD). Interventions: The patient was asked to stop alcohol consumption, and was prescribed with B-vitamins (thiamine, B6, B12) to improve his symptoms. Outcomes: After one week of treatment, the patient could communicate with others fluently. His memory improved significantly. Conclusion: Acute MBD is not always fatal; early diagnosis and prompt treatment can greatly improve its prognosis. Radiological findings can aid the clinical diagnosis of MBD. The lesions are usually localized in or spread throughout the corpus callosum.
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