Abstract
Petroff et al. (p. 709) assessed homocarnosine, GABA, and pyrrolidone by MRS in patients with complex partial seizures (CPS) and juvenile myoclonic epilepsy (JME). Low GABA levels were associated with poor seizure control in CPS. Increased homocarnosine levels were associated with improved seizure control in both JME and CPS.In the accompanying editorial (p. 698), Henry and Theodore note that MRS has the potential to provide a means of assessing adequacy of seizure treatment if it can be established that homocarnosine mediates antiseizure effects of antiepileptic drugs. MRS could serve as a surrogate marker preferable to the clinical estimate of seizure frequency, particularly in CPS in which patients and caregivers are not aware of the seizures. Sakuri et al. (p. 778) report a man who developed an inability to read Japanese phonograms (kana) with preservation of the ability to read morphograms …
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