Abstract
Resumo Objetivo: Identificar as variações nos níveis de marcadores de hemólise em CH administrados por CCIP segundo o calibre do cateter. Método: Estudo experimental realizado em laboratório com condições de temperatura e umidade controladas. A amostra teve 36 alíquotas de sangue de 10 bolsas de hemácias com tipo de sangue A+; infusão de gravidade foi utilizada em seis CCIP de 3Fr (French) e seis de 4Fr, totalizando 12 experimentos divididos em três tempos: basal, fluxo livre e fluxo controlado. Analisou-se grau de hemólise, valores totais e livres de hemoglobina, desidrogenase láctica e potássio. Resultados: Houve aumento da média de hemoglobina livre (p=0,01) e grau de hemólise (p=0,01) após infusão de fluxo livre, com média de elevação de 0,04 de potássio (p<0,01) e redução de hemoglobina total (p=0,01) em fluxo controlado. O concentrado de hemácias aplicadas em 4Fr CCIP teve média de elevação de grau de fluxo. O CCIP de 3Fr teve aumento médio significante em grau de hemólise (p=0,03) e hemoglobina livre (p=0,01) após controle do fluxo. Conclusão: O CCIP de 4Fr foram associados a maiores mudanças nos marcadores de hemólise. Maior dimensão do calibre pode proporcionar fluxo turbulento, contribuindo para um maior choque entre as hemácias.
Highlights
The packed red blood cells (PRBC) are one of the blood components most used in hemotherapy.[1]
Hemolysis is usually identified in blood products due to the presence of plasma free hemoglobin (PFHb) that reacts with oxygen and nitric oxide, resulting active forms of iron and free heme, able to activate the immune response of macrophages and monocytes
It should be noted that the inclusion of bags according to time of storage was at random, so that 67% of the 3Fr peripherally inserted central catheter (PICC) experiments occurred with PRBC with less than 14 days, while in 4Fr PICC these were used in 83% of the experiments
Summary
The packed red blood cells (PRBC) are one of the blood components most used in hemotherapy.[1]. Nous punctures and costs of materials and professionals involved in this procedure.[14] factors such as prolonged length of stay, less traumatic peripheral insertion and reduced risk of complications, when compared to other central catheters, makes it the first option after umbilical catheter removal.[15]. Elements such as infusion rate, size and length of the catheter used, method of administration, storage time of red blood cells, as well as the hematocrit (HcT) value are factors that may influence on the quality of the blood product administered. The study had as objective to evaluate the change in hemolysis markers in PRBC, administered by gravity infusion in non-valved PICC lines, according to different sizes
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
