Abstract
The DNA markers such as Short Tandem Repeats (STR) can be applied to assess the genetic diversity among the populations. A representative sample of 246 individuals was randomly selected from all nine provinces of Sri Lanka. Buccal swabs were collected from the participants to obtain genetic data from 22 loci. The purpose of this study was to determine the allele frequencies at each locus and compare them statistically between different provinces. The allele frequencies of each locus in one province were statistically evaluated separately with all the other eight provinces. For each province, the number of loci that differed significantly from the rest of the eight provinces was calculated. The southern, Eastern, Northern, and Central provinces showed a higher number of significantly different loci (91, 85, 84, and 84 respectively) among all other provinces. The ethnic barrier as well as the geographical barriers may cause the genetic isolation of the above provinces
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