Abstract
Mapping the pathophysiology of schizophrenia: interactions between multiple cellular pathways
Highlights
Schizophrenia is a complex disorder involving dysregulation of multiple pathways in its pathophysiology with strong evidence to support roles for dopaminergic, glutamatergic, GABAergic, and cholinergic neurotransmitter systems and their interactions in the pathophysiology of the disorder (Benes, 2009; Karam et al, 2010; Gibbons et al, 2013)
Snyder and Gao (2013) provide an excellent review of NMDA receptor hypofunction hypothesis, suggesting NMDA receptor hypofunction as a convergence point for progression and symptoms of schizophrenia. They discuss evidence on altered NMDA receptor subunits in schizophrenia and how these alterations interact with multiple schizophrenia susceptibility genes that lead to NMDA receptor dysfunction during development (Snyder and Gao, 2013)
Scarr et al (2013) present an in depth and very detailed coverage of cholinergic involvement in schizophrenia and how it interacts with other neurotransmitters including glutamate, dopamine, GABA and serotonin, as well as its links with the inflammatory/immune system
Summary
Schizophrenia is a complex disorder involving dysregulation of multiple pathways in its pathophysiology with strong evidence to support roles for dopaminergic, glutamatergic, GABAergic, and cholinergic neurotransmitter systems and their interactions in the pathophysiology of the disorder (Benes, 2009; Karam et al, 2010; Gibbons et al, 2013). The first four articles focus on the roles and interactions of neurotransmitters in the pathophysiology of psychiatric disorders.
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