Mapping the human brainstem: Brain nuclei and fiber tracts at 3 T and 7 T.

Abstract

Structural high-resolution imaging of the brainstem can be of high importance in clinical practice. However, ultra-high field magnetic resonance imaging (MRI) is still restricted in use due to limited availability. Therefore, quantitative MRI techniques (quantitative susceptibility mapping [QSM], relaxation measurements [ , R1 ], diffusion tensor imaging [DTI]) and T2 - and proton density (PD)-weighted imaging in the human brainstem at 3 T and 7T are compared. Five healthy volunteers (mean age: 21.5±1.9years) were measured at 3 T and 7T using multi-echo gradient echo sequences for susceptibility mapping and relaxometry, magnetization-prepared 2 rapid acquisition gradient echo sequences for R1 relaxometry, turbo-spin echo sequences for PD- and T2 -weighted imaging and readout-segmented echo planar sequences for DTI. Susceptibility maps were computed using Laplacian-based phase unwrapping, V-SHARP for background field removal and the streaking artifact reduction for QSM algorithm for dipole inversion. Contrast-to-noise ratios (CNRs) were determined at 3 T and 7T in ten volumes of interest (VOIs). Data acquired at 7T showed higher CNR. However, in four VOIs, lower CNR was observed for at 7T. QSM was shown to be the contrast with which the highest number of structures could be identified. The depiction of very fine tracts such as the medial longitudinal fasciculus throughout the brainstem was only possible in susceptibility maps acquired at 7T. DTI effectively showed the main tracts (crus cerebri, transverse pontine fibers, corticospinal tract, middle and superior cerebellar peduncle, pontocerebellar tract, and pyramid) at both field strengths. Assessing the brainstem with quantitative MRI methods such as QSM, , as well as PD- and T2 -weighted imaging with great detail, is also possible at 3T, especially when using susceptibility mapping calculated from a gradient echo sequence with a wide range of echo times from 10.5 to 52.5ms. However, tracing smallest structures strongly benefits from imaging at ultra-high field.