Mapping the community structure of the rat cerebral cortex with weighted stochastic block modeling.

Abstract

The anatomical architecture of the mammalian brain can be modeled as the connectivity between functionally distinct areas of cortex and sub-cortex, which we refer to as the connectome. The community structure of the connectome describes how the network can be parsed into meaningful groups of nodes. This process, called community detection, is commonly carried out to find internally densely connected communities-a modular topology. However, other community structure patterns are possible. Here we employ the weighted stochastic block model (WSBM), which can identify a wide range of topologies, to the rat cerebral cortex connectome, to probe the network for evidence of modular, core, periphery, and disassortative organization. Despite its algorithmic flexibility, the WSBM identifies substantial modular and assortative topology throughout the rat cerebral cortex connectome, significantly aligning to the modular approach in some parts of the network. Significant deviations from modular partitions include the identification of communities that are highly enriched in core (rich club) areas. A comparison of the WSBM and modular models demonstrates that the former, when applied as a generative model, more closely captures several nodal network attributes. An analysis of variation across an ensemble of partitions revealsthat certain parts of the network participate in multiple topological regimes. Overall, our findings demonstrate the potential benefits of adopting the WSBM, which can be applied to a single weighted and directed matrix such as the rat cerebral cortex connectome, to identify community structure witha broad definition that transcends the common modularapproach.