Abstract
Antibodies in blood provide a rich source of immunological information. Antibody repertoire analysis seeks to decode this information to empower the development of vaccines, diagnostics, and therapeutics. To this end, various approaches have been developed to determine epitopes using peptide libraries. Approaches have used random or proteome-derived peptide libraries in a microarray or surface display format. For methods using random libraries, motif discovery software has been developed to identify common binding signatures. The analysis of thousands of samples and dozens of diseases has shown that there are often disease-specific epitopes, even though individual antibody repertoires are unique. The recent developments in antibody repertoire analysis hold the potential to enable comprehensive immune evaluations.
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