Abstract
Recent studies have investigated the control of adipose tissue expansion and inflammatory process by microRNAs (miRNAs). These two processes are of great interest because both are associated with obesity and metabolic syndrome. However, despite the great relevance of the role of miRNAs in obesity and adipose tissue, no qualitative and quantitative analysis on the subject has been performed. Thus, we aimed to examine global research activity and current trends with respect to the interaction between obesity, adipose tissue and miRNAs through a bibliometric analysis. This research was performed on the Scopus database for publications containing miRNA, obesity, and adipose tissue keyword combinations. In total, 898 articles were analyzed and the most frequently occurring keywords were selected and clustered into three well-defined groups. As a result, first group of keywords pointed to the research area on miRNAs expressed in obesity-associated diseases. The second group demonstrated the regulation of the adipogenesis process by miRNAs, while the third group highlighted brown adipose tissue and thermogenesis as one of the latest global research trends related to the theme. The studies selected in this paper describe the expression and performance of different miRNAs in obesity and comorbidities. Most studies have focused on identifying miRNAs and signaling pathways associated with obesity, type 2 diabetes mellitus, and cardiovascular disease. Thus, the miRNA profile for these diseases may be used as biomarkers and therapeutic targets in the prevention and treatment of obesity-associated diseases.
Highlights
The prevalence of obesity has increased worldwide and reached pandemic levels in modern society [1,2] A recent global burden estimate suggests that over 1.9 billion people are obese or overweight [3], and about 4 million people die each year from complications related to obesity [1]. there have been countless efforts to reduce the progress of obesity, in 2025, the worldwide public health costs related to this condition will reach $1.2 trillion [4]
Peng et al demonstrated that miR-221 is up-regulated in white adipose tissue and acts as a pro-inflammatory miRNA involved in the development of type 2 diabetes [74]
Recent studies have shown that adipogenesis is a in adipocytes, increasing the release of free fatty acids into the circulation and the risk of physiological lipotoxicity comprising potential be used a pharmacological to that combat obesity-induced inprocess peripheral tissues the such as the to liver
Summary
The prevalence of obesity has increased worldwide and reached pandemic levels in modern society [1,2] A recent global burden estimate suggests that over 1.9 billion people are obese or overweight [3], and about 4 million people die each year from complications related to obesity [1]. Periods of prolonged positive energy balance promote the excessive accumulation of triglycerides and morphological changes that trigger an immune response and pro-inflammatory cytokines secretion, leading to low-grade inflammation [11,12] These conditions are associated with the development of obesity-related metabolic disorders, such as type 2 diabetes mellitus, cardiovascular disease, and cancer [13,14,15]. The analysis of bibliometric related obesity, adipose tissue, and miRNAs variables regarding these matters remains elusive. 2. Materials and Methods update related to obesity and miRNAs by employing a bibliometric analysis. The Scopus database was selected to perform literature search, it isinvestigators considered to Prism version 7 and R Studio version 1.1.463 were used for statistical analysis and to create charts
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