Abstract
and egam2e 1Neu show similar phenotypes although there are differences in the degree of the PGAM activity elevation. Linkage analyses localized Pgam2e 1Neu to the distal region of Chr 4 between markers D4Mit134 and D4Mit54 (Fig. 1). Thus, a second locus for increased PGAM activity in the mouse genome has been identified. We have recovered and maintained a total of 15 mutations with altered PGAM activity in an extensive series of mutagenesis experiments. Further studies will be undertaken to determine allelism with the Pgam structural locus as well as with Pgamle or Pgam2e.
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