Abstract
In the present study, our purpose was to identify candidate gene(s) influencing initial dental caries susceptibility on chromosomes 7 and 11 using a Quantitative Trait Loci (QTL) analysis. On chromosome 7, five suggestive QTLs were detected in D7Mit31, D7Mit148, D7Mit262, D7Mit126 and D7Mit101. On chromosome 7, the peak LRS score was located in a region 50 cM from the centromere between marker D7Mit31 and PTH . On chromosome 11, five significant QTLs were detected in D11Mit242, D11Mit26, D11Mit339, D11Mit177 and D11Mit262. On chromosome 11, one highly significant QTL was detected in Kcnj12 , the peak LRS score was located in a region 34.15 cM from the centromere marker Kcnj12 . These results suggest that Kcnj12 on chromosome 11 might be one of the major gene(s) responsible for initial dental caries susceptibility.
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