Abstract
Surface-enhanced Raman scattering (SERS) has been applied in a range of fields for its super high sensitivity which can even reach the single molecule level. But the quantification methods based on SERS still have some challenges such as stability, repeatability, and linearity at low concentrations. Here we propose a new quantification approach by using a total mapping scheme, and then add all the spectra together to obtain a final merged spectrum (a total SERS spectrum). The total SERS spectra were used to perform quantification analysis. The results of this approach show that it can improve the signal stability by at least 50% (RSD) and extend the linear quantification range by one order of magnitude. The proposed total SERS mapping quantification strategy is a promising practical working mode to improve its analytical figures of merit.
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