Abstract

BackgroundPaediatric cancers account for a minor fraction of deaths and hence receive little attention from policymakers. In low-income countries, the absence of comprehensive national paediatric strategies results in a lack of access for a majority of children with cancer. In sub-Saharan Africa (SSA), the burden of childhood cancers is underestimated due to a lack of paediatric cancer registries, poor health care systems and competing healthcare needs. The objective of this study is to map evidence on the distribution of paediatric cancers in the SSA region.MethodA scoping review will be conducted to map literature on the distribution of paediatric cancers in SSA. An electronic literature search will be conducted from the following databases: PubMed, Google Scholar, EBSCOhost (CINAHL and Health Source) and World Health Organization (WHO)/International Agency for Research in Cancer (IARC) (GLOBOCAN databases). We will also search the reference lists of included studies to source relevant literature. A pilot search was conducted to determine the feasibility of the study. Study selection will be guided by the inclusion and exclusion criteria. After charting the data, a descriptive overview of the studies will be presented in a narrative format. An account of the study characteristics will be described in this narrative. The analysis will be mainly based on mapping the country-specific outcomes emerging from the studies, and a numerical summary of these outcomes will be conducted. Tables, maps and charts will be produced and presented in the result section.DiscussionThis review study will identify existing research gaps for future research to influence policy implementation and to improve the availability of diagnosis and treatment of paediatric cancers in SSA.

Highlights

  • Paediatric cancers account for a minor fraction of deaths and receive little attention from policymakers

  • This review study will identify existing research gaps for future research to influence policy implementation and to improve the availability of diagnosis and treatment of paediatric cancers in sub-Saharan Africa (SSA)

  • In high-income countries (HIC), it is estimated that 2.5% of children with human immunodeficiency virus1 (HIV) will develop cancer [9]

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Summary

Introduction

Paediatric cancers account for a minor fraction of deaths and receive little attention from policymakers. In sub-Saharan Africa (SSA), the burden of childhood cancers is underestimated due to a lack of paediatric cancer registries, poor health care systems and competing healthcare needs. The objective of this study is to map evidence on the distribution of paediatric cancers in the SSA region. The estimated 5-year prevalence of cancers in 2018 for children 14 years and below is 606,982 [2]. In 2018, the estimated number of prevalent paediatric cancers is 103,016 [2]. The prevalence rates in Africa may be underestimated due to a lack of proper diagnosis and childhood cancer registration [3, 4]. The actual distribution of these malignancies in SSA is not truly reflected because of poor health care systems and competing health care needs, making it difficult to develop paediatric cancer control programmes [5]

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