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Abstract
Epigenetic modifications (chemical changes to the four canonical DNA bases) are responsible for important processes like cell differentiation, yet epigenetic abnormalities are associated with diseases like cancer. Thus the epigenome is a better indicator of cell health than is the genome itself. Familiar sequencing techniques, however, are insensitive to base modifications. The authors show that the most common epigenetic modifications can be detected via their tunneling-current signatures, right alongside the usual DNA bases, in a single run through a nanopore. Using current-current correlations, the modified bases can be identified with any preselected accuracy.
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