Abstract
Guanosine-5’-triphosphate (GTP) is a nucleotide serving as an energy source and substrate in multiple reactions including protein synthesis, cellular signal transduction, as a precursor for pterin cofactor synthesis, and a substrate in RNA synthesis. Erythrocytes from inbred strains of mice exhibit a 10–14 fold variation in GTP concentration, but a comparison of enzymes involved in guanine metabolism did not reveal the basis for the variation in cellular GTP concentration. We describe here a genetic analysis of the erythrocytic guanine nucleotide concentration determining trait which we have designated Gtpc.
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