Abstract
This paper reports a new bioactive surface based on magnetic microspheres with an average size up to 500 nm. Magnetic microspheres consisting of 8 nm magnetite nanoparticles functionalized with Melissa officinalis essential oil, poly lactic acid and chitosan were prepared using a solvent evaporation method and pelliculized by MAPLE. The as prepared surface was characterized by X-ray diffraction, infrared and scanning electron microscopy. The in vitro experiments revealed a good compatibility with eukaryotic cells a significant inhibitory activity of the prokaryotic cells adherence properties. This approach could be a successful method to control and prevent microbial biofilms associated infections and may be also used as an alternative strategy to limit the consumption of synthetic antimicrobial drugs in order to decrease the rates of microbial resistance to antibiotics.
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