Abstract
Meso-Xanthin (Meso-Xanthin F199™) is a highly active antiaging injection drug of the latest generation. The main acting compound is fucoxanthin, supplemented with several growth factors, vitamins, and hyaluronic acid. Previous examination of fucoxanthin on melanocytes showed its ability to inhibit skin pigmentation through different signaling pathways focused on suppression of melanogenic-stimulating receptors. In turn, the anticancer property of fucoxanthin is realized through MAPK and PI3K pathways. We aimed to evaluate the effect of fucoxanthin and supplemented growth factors on melanocyte growth and transformation at a proteomic level. The effect of fucoxanthin on melanocytes cultivated in three-dimensional (3D) condition was examined using high-throughput proteomic and system biology approaches to disclose key molecular events of the targeted action. Our results demonstrated significant inhibition of cell differentiation and ubiquitination processes. We found that the negative regulation of PSME1 and PTGIS largely determines the inhibition of NF-κB and MAPK2. Besides, fucoxanthin selectively inhibits cell differentiation via negative regulation of Raf signaling and the upstream activation of IL-1 signaling. It is assumed that inhibition of Raf influences the Notch-4 signaling and switches off the MAPK/MAPK2 cascade. Blockage of MAPK/MAPK2 is feasible due to suppression of Ras and NF-κB by the addressed action of IKKB, IKK2, and TRAF6. Suggestively, Meso-Xanthin F199™ can manage processes of proliferative activity and inhibition of apoptosis due to composition of fucoxanthin and growth-stimulating factors, which may increase the risk of skin cancer development under certain condition.
Highlights
Meso-Xanthin, commonly known under the trademark MesoXanthin F199TM, is a highly active antiaging drug of the latest generation, recently developed by the ABG Lab LLC (USA), and recommended to patients under 40 years of age
We aimed to evaluate the effect of fucoxanthin and supplemented growth factors on melanocyte growth and transformation at a proteomic level
We found that the negative regulation of PSME1 and PTGIS largely determines the inhibition of NF-κB and MAPK2
Summary
Meso-Xanthin, commonly known under the trademark MesoXanthin F199TM, is a highly active antiaging drug of the latest generation, recently developed by the ABG Lab LLC (USA), and recommended to patients under 40 years of age. It consists of several acting compounds, the main of which is fucoxanthin (FX), supplemented with vitamins (A, C, and E), hyaluronic acid, and growth factors (EFG, IGF-2, and βEGF). The main compound with the exact antioxidant property, fucoxanthin, is one of the most abundant carotenoids isolated from brown seaweeds and diatoms. The structure of FX is affected by heating and UV light exposure [1]. Recent studies demonstrated a wide variety of biological properties of FX promising in treatment and prevention of obesity [2], cancer development [3], and diabetes mellitus [4]
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