Abstract
Brachyury gene, firstly discovered in 1927, encodes a protein of 435 amino acids, which functions as a transcription factor regulating posterior mesoderm formation and notochord differentiation, and plays many roles in carcinogenesis and other some biological process.
Highlights
Brachyury gene, firstly discovered in 1927, encodes a protein of 435 amino acids, which functions as a transcription factor regulating posterior mesoderm formation and notochord differentiation, and plays many roles in carcinogenesis and other some biological process.Brachyury in notochord formation and notochord cell-derived cellsBrachyury is essential to maintain notochord cell fate and function [1]
The origin of intervertebral disc cells is always considered to be associated with notochord cells
Our research has found that Brachyury can protect the intervertebral disc cells from degeneration
Summary
Submission: May 20, 2021 Published: May 25, 2021 Volume 5 - Issue 5 How to cite this article: Ming Chen, Keqin Shi, Jun Shen.
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