Abstract
Wound dressings able to deliver topically bioactive molecules represent a new generation of wound-regeneration therapies. In this article, foams based on methylcellulose cross-linked with Manuka honey were used as a platform to deliver borate bioactive glass particles doped additionally with copper. Borate bioactive glasses are of great interest in wound-healing applications due to a combination of favorable features, such as angiogenic and antibacterial properties. The multifunctional composite providing the dual effect of the bioactive glass and Manuka honey was produced by freeze-drying, and the resulting foams exhibit suitable morphology characterized by high porosity. Moreover, the performed tests showed improved wettability and mechanical performance with the addition of bioactive glass particles. Dissolution studies using simulated body fluid and cell biology tests using relevant skin cells further proved the excellent bioactivity and positive effects of the foams on cell proliferation and migration. Most interestingly, by the dual release of Manuka honey and ions from the copper-doped bioactive glass, an antibacterial effect against E. coli and S. aureus was achieved. Therefore, the multifunctional foams showed promising outcomes as potential wound dressings for the treatment of infected wounds.
Highlights
Skin, the largest organ covering the entire body, has several pivotal functions including body temperature regulation, synthesis of vitamin D3, immunological surveillance, and prevention of water loss [1, 2]
We present the development of foams based on MC crosslinked with Manuka honey (MH) and loaded with borate bioactive glass (BG) particles by freeze drying
In the studies reported in the literature related to the use of MH in combination with other compounds for food or biomedical applications, the typical FTIR bands related to the presence of methylglyoxal, responsible for the antibacterial properties of MH, are not reported
Summary
The largest organ covering the entire body, has several pivotal functions including body temperature regulation, synthesis of vitamin D3, immunological surveillance, and prevention of water loss [1, 2]. To guarantee an effective wound-healing process, several set conditions as temperature and oxygenation, as well as high availability of minerals, vitamins, and trace elements, are necessary at the wound site [1]. These conditions can be negatively influenced by contaminations, which can lead to deterioration of growth factors, extracellular matrix, and granulation tissue [1, 3]. The goal of research on skin regeneration and wound healing is to support the human body to heal the wound in the shortest period of time with a minimum of scarring, pain, and discomfort of the patient [4]
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