Manufacturing and Computational Fluid Dynamics Modeling of a Patient-Specific Fistula Model

Abstract

Arteriovenous fistula is the joining of an artery to a vein to create vascular access for dialysis. The failure or maturation of fistula is affected by the vessel wall shear stress (WSS), which is difficult to measure in clinic. A computational fluid dynamics (CFD) model was built to estimate WSS of a patient-specific fistula model. To validate this model, a silicone phantom was manufactured and used to carry out a particle imaging velocimetry (PIV) experiment. The flow field from the PIV experiment shows a good agreement with the CFD model. From the CFD model, the highest WSS (40 Pa) happens near the anastomosis. WSS in the vein is larger than that in the artery. WSS on the outer venous wall is larger than that on the inner wall. The combined technique of additive manufacturing, silicone molding, and CFD is an effective tool to understand the maturation mechanism of a fistula.