Abstract
A 51-year-old female patient, who had been diagnosed with mantle cell lymphoma for 20 months, was admitted to the hospital for erythematous nodules on extremities for 10 days. Physical examination showed left cervical and submaxillary lymphadenectasis as well as bilateral enlarged palatine tonsils (grade Ⅱ) . Histopatholo-gical examination of skin lesions on the left upper limb revealed diffuse infiltration of small lymphocytes in dermis and subcutaneous tissue. Immunohistochemical examination showed positive staining for CD5, Bcl-2, CD43, CD20, CyclinD1, λ chain and Ki-67 (> 70 %) , but negative staining for CD3, C10, Bcl-6, CD23, CD21 and κ chain. Fluorescence in situ hybridization (FISH) showed the absence of the t (11:14) /CCND1-IGH fusion gene. The patient was diagnosed as mantle cell lymphoma with skin involvement. After treatment with cyclophosphamide, doxorubicin, vincristine and prednisone, the condition was controlled and follow up was underway. Key words: Lymphoma, mantle-cell; Skin diseases; Rare diseases
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