Abstract
We present a case of a 61 year old man admitted for epigastric pain and fatigue. Computed tomography and endoscopy revealed the presence of a gastric mass and multiple polyps in the duodenum. The patient also had widespread lymphadenopathy, ascites and pleural effusion. Genetic and immunohistochemical testing confirmed the diagnosis of disseminated mantle cell lymphoma. To the best of our knowledge, we are the first to describe a case of simultaneous gastric and duodenal mantle cell lymphoma.
Highlights
Mantle cell lymphoma (MCL) is a rare malignancy reported mainly through case reports [1,2]
The findings of our case are consistent with a CD5-positive mature B-cell neoplasm, and the overall histopathologic pattern is that of a mantle cell lymphoma of the gastrointestinal tract (GI) tract
Our case is unique amongst previous case reports on gastrointestinal MCL in that it describes a case with a gastric mass and multiple lymphomatous polyposis (MLP) simultaneously
Summary
Mantle cell lymphoma (MCL) is a rare malignancy reported mainly through case reports [1,2]. In up to 80% of cases of MCL, patients have involvement of extranodal sites and organs like the spleen, bone marrow, peripheral blood, gastrointestinal tract (GI), etc [10]. Median survival with treatment is 4 to 5 years [19] In this case report, we present a patient with disseminated MCL that primarily involved the stomach and duodenum. A 61 year-old, male patient, of South-Asian ethnicity, presented to the emergency room complaining of epigastric pain, general fatigue, shortness of breath and abdominal distention of a couple of months duration He has a past medical history significant for long-standing type 2 diabetes mellitus The patient’s general condition rapidly worsened and within a month, he succumbed to septic shock, with blood and ascetic fluid cultures growing the yeast Candida glabrata
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