Mantle cell lymphoma of the colon

Abstract

An 81-year-old man with a history of stage IV mantle cell lymphoma (MCL) diagnosed from a submental lymph node biopsy in 2006 was evaluated for new-onset melena and blood clots with bowel movements. He had been treated for his MCL with 6 cycles of CHOP-R (cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab) in 2006, followed by 13 cycles of maintenance rituximab. In 2012, he was started on lenalidomide (Revlimid), but decided to stop after an exacerbation of his heart failure. On presentation, his hemoglobin was 5.2g/dL. Colonoscopy showed a 4-cm mass in the cecal base (● Fig.1), a 5-cm ulcerated mass encircling the ileocecal valve, and six sessile odd-looking polypoid masses in the cecal base. Biopsy was consistent with MCL (● Fig.2, ● Fig.3, ● Fig.4,● Fig.5). Because of the patient’s heart failure, surgical resection was not favored. He was started on radiotherapy and chlorambucil. MCL is one of the mature B-cell nonHodgkin lymphomas. Most patients with MCL present with advanced-stage disease, and up to 80% have involvement of extranodal sites, including the spleen, bone marrow, and gastrointestinal tract. Gastrointestinal tract involvement was detected in 10%–28% of MCL cases in various series [1,2]. The typical appearance of intestinal MCL is multiple lymphomatous polyposis. Less commonly, it appears as protruded lesions or superficial lesions. MCL expresses pan-B-cell antigens, CD5, and FMC7. Cyclin D1 is helpful to distinguish MCL from other lymphomas.