Abstract
Non Hodgkin's Lymphoma (NHL) in Human Immunodeficiency Virus (HIV) infection is an Acquired Immunodeficiency Syndrome (AIDS) defining malignancy which can present with generalized lymphadenopathy. HIV itself has a 60-to-200-fold increase in risk for NHL, and most of the NHL in HIV infection are aggressive B cell-type with wide histological variation. Primary Central Nervous System lymphoma (PCNSL) and Burkitt lymphoma (BL) are the two most common types of Diffuse Large B-cell Lymphomas (DLBCL) associated with HIV infection. Mantle Cell Lymphoma (MCL) is a rare and aggressive form of NHL arising from the "Mantle Zone" of the lymph nodes. MCL is not a common type of NHL described in HIV infection. We report a case of MCL in 34-year-old HIV-infected women presented with generalized lymphadenopathy and hepatosplenomegaly in Sri Lanka. Failure to adhere to antiretroviral therapy leading to uncontrolled HIV viral load and low CD4 count as risk factors for developing rare MCL is discussed.
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