Abstract
Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.
Highlights
The first natural isoquinolinequinone isolated from bacteria were reported by Fukum et al
A few others were isolated from porifera, including cribrostatins [3], renierones [4,5], and caulibugulones [6]
After extraction and chromatographic separation, the strain B1748 strain B1748 afforded under these conditions the mansouramycins A (5) and D (6) and afforded under these conditions the mansouramycins A (5) and D (6) and three new three new congeners, the mansouramycins E–G (1a–3a) as dark red solids
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. A few others were isolated from porifera, including cribrostatins (produced by the blue marine sponge Cribrochalina sp.) [3], renierones (from Reniera, Petrosia, and Haliclona spp.) [4,5], and caulibugulones (found in the marine bryozoon Caulibugula inermis) [6]. These isoquinolinequinones showed a potent antimicrobial activity against Gram positive bacteria and yeast (Candida albicans) and a pronounced cytotoxicity against L1210 and other cell lines with IC50 values as low as.
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