Abstract
AbstractIn living organisms, carbohydrate‐protein interactions play key roles in physiological and pathological processes, which are amplified by the “glycol‐cluster effect.” In this work, we synthesized novel fluorescent cellulose derivatives bearing mannose moieties via thiol‐ene click reactions by sequentially conjugating hydrophilic mannose‐oxyethoxylpropane‐thiol (Mann‐SH) and fluorescent coumarin‐oxyhexyl‐thiol (Coum‐SH) and rhodamine B‐ethyl‐thiol (RhB‐SH) to cellulose undecenoate with terminal double bonds. The amphiphilic fluorescent cellulose derivatives were converted into nanoparticles (NPs) by dropping into low ionic strength solutions (<0.085 M). Obtained NPs have average sizes between 240 and 554 nm depending on the solution concentrations, exhibiting uniform size distributions (PDI values <0.12). These uniform NPs exhibited excellent dispersion stability even at elevated temperatures. The mannose moieties were accessible to 1,4‐benzenediboronic acid (BDBA) in NaOH aqueous solutions. Under irradiation with UV light of 320–400 nm, the fluorescence of NPs increased by the formation of open‐ring rhodamine spiroamide, which could be a promising candidate for biomedical application.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.