Mannose Binding Lectin Levels Was Not Associated with Resistance to Tuberculosis Infection in the Population of Uyo Metropolis in Nigeria

Inyang U Udosen ,Anietie E Samuel ,Monday I Akpanabiatu ,Imo Y Sandy

doi:10.7176/jnsr/12-14-02

Abstract

Mannose-binding lectin (MBL2) is an important pattern recognition molecule that identifies and binds to specific sugar molecules on the surface of pathogens thereby activating its destruction by the immune system. Samples for study were recruited from Uyo metropolis of Akwa Ibom state in Nigeria. In this study, levels of MBL2 was measured by enzyme-linked immunosorbent assay in tuberculosis patients and healthy individuals to determine if the immune protein protects against tuberculosis infection. MBL2 levels in tuberculosis patients and healthy controls were 14.0ng/ml ± 13.9 and 19.9ng/ml ± 18.5 respectively. The results from the study showed that there was no association in MBL2 levels between tuberculosis and controls (p=0.107) as well as between the different sub-groups. Therefore, MBL2 is not a contributory factor in resistance against tuberculosis in the population under study. Keywords: Mannose binding lectin, tuberculosis, pattern recognition molecule, immune system DOI: 10.7176/JNSR/12-14-02 Publication date: July 31 st 2021

Highlights

Mannose-binding lectin (MBL), known as mannose-binding protein, mannan-binding protein and corespecific lectin (Turner, 1996) is classified among the collectin protein family characterized by the possession of a collagenous region and a lectin domain (Auriti et al, 2017)
The assay result showed that the mean levels of MBL2 in healthy controls was 19.9ng/ml ± 18.52 while that of tuberculosis cases was 14.0ng/ml ± 13.92 (Table 1)
The t-test analysis of MBL2 levels in tuberculosis patients and healthy controls showed no significant difference between the two groups (p= 0.107)

Summary

Introduction

Mannose-binding lectin (MBL), known as mannose-binding protein, mannan-binding protein and corespecific lectin (Turner, 1996) is classified among the collectin protein family characterized by the possession of a collagenous region and a lectin domain (Auriti et al, 2017) It is a pattern recognition molecule which recognizes and binds to exposed specific sugar surfaces of microorganisms thereby triggering immune response (Takahashi et al, 2006). MBL acts against a wide variety of microorganisms including bacteria (aerobic and anaerobic), fungi and viruses as well as parasites (Neth et al, 2000; Townsend et al, 2001; Ezekowitz et al, 1989; Ying et al, 2004) This underlines the role of MBL in first-line immune defense against pathogens. The binding of the MBL to microbial surface carbohydrates activates the lectin complement pathway and enhances opsonophagocytosis (Neth et al, 2002)

Methods

Results

Conclusion