Abstract
Mannose-binding lectin 2 (MBL2) is a serine protease which is believed to be an important factor in the inherited immune system. In this article, we present a coronavirus disease 2019 (COVID-19) family of five patients: a 56-year-old father, a 51-year-old mother, two sons aged 23 and 21 years, and a 15-year-old daughter. According to the results of MBL2 rs1800450 variant analysis performed, the father had homozygous mutant, the mother had homozygous normal, and the three children had heterozygous mutant genotype. When we compared the clinical parameters and genotypes, MBL2 gene polymorphism plays a very important role in COVID-19 susceptibility and severe disease. The family, which makes up our study, is the proof of this situation, and it contains important implications for host factors and COVID-19.
Highlights
Coronavirus disease 2019 (COVID-19) is a pandemic that has infected many people since the first case was announced and has been among the major infectious events of the century
One of the different host factors can be mentioned from the literature: Mannose-binding lectin 2 (MBL2) is a serine protease belonging to the collectin family and is believed to be an important factor in the inherited immune system
The MBL2 genetic polymorphism was analyzed using the same method, and we present a COVID-19 family of five patients that was proven in parallel with main study.[8]
Summary
Coronavirus disease 2019 (COVID-19) is a pandemic that has infected many people since the first case was announced and has been among the major infectious events of the century. The MBL2 protein binds to the surface of a wide range of microorganisms by its ability to recognize or function directly as an opsonin or through activation of the complement system, increasing the phagocytosis of microorganisms by macrophages and neutrophils.[4] There are several known polymorphisms in the MBL2 gene (10q21.1), located on the long arm of chromosome 10, in both the promoter and exon regions, resulting in multiple haplotypes These genetic polymorphisms are associated with different levels of MBL expression and activity.[4,5] Various studies on the association of MBL2 genetic polymorphism and/or MBL plasma levels with severe infections, sepsis, and septic shock have shown an increased risk of developing sepsis in patients with MBL deficiency and a negative outcome.[5,6].
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