Abstract
ABSTRACT. A study was undertaken to evaluate hypertonic mannitol treatment in experimental lapin Haemophilus influenzae type b meningitis and to compare these results with those in normal rabbits. Increased intracranial pressure, brain water content, and concentrations of lactate and hypoxanthine in cerebrospinal fluid (CSF) were measured as a reflection of altered cerebral perfusion and hypoxia and potential brain injury associated with meningitis. A single dose of mannitol reduced transiently the CSF pressure of uninfected rabbits from 2.15 ± 0.20 to 1.34 ± 0.10 mm Hg (maximum reduction 34.9 ± 8.4%; p 0.05). CSF lactate and hypoxanthine concentrations were significantly increased during the 20 h of meningeal inflammation (p < 0.005). The mean percentage change from baseline values for lactate concentrations at the end of the experiment (24 h) in infected mannitol-treated rabbits was significantly smaller than that in infected untreated animals (p = 0.035). A single dose of mannitol reduced the CSF hypoxanthine concentrations of infected animals, but this reduction was not statistically significant.
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