Abstract
1. Microbes versus microbes: control of pathogens in the food chain Kieran Jordan, Marion Dalmasso, Juergen Zentek, Anneluise Mader, Geert Bruggeman, John Wallace, Dario De Medici, Alfonsina Fiore, Estella Prukner-Radovcic, Maja Lukac, Lars Axelsson, Askild Holck, Hanne Ingmer, Mindaugas Malakauskas Journal of the Science of Food and Agriculture CrossRef
Highlights
Oligosaccharides, mannanoligosaccharides (MOS), appeared to be very hopeful growth promoters for livestock
There was no considerable difference between MOS-M and MOS-H groups, the birds fed the diet containing high level of MOS significantly differed in body weight gain only from the flavomycin receiving turkeys
Our studies revealed that flavomycin in a dose 8 mg per kg feed mixture significantly decreased the amount of enterobacteria cells attached to colonic epithelium
Summary
Oligosaccharides, mannanoligosaccharides (MOS), appeared to be very hopeful growth promoters for livestock. Available mannanoligosaccharides are complex carbohydrates extracted from cell wall of yeast Saccharomyces cerevisiae. As entirely safe compounds, MOS appeared to be promising in suppressing enteric pathogens, modulating immune response, and improving integrity of the intestinal mucosa (Iji et al, 2001; Swanson et al, 2002; Elmusharaf et al, 2006). MOS prevent bacterial infection via mechanisms that are different from antibiotics, and circumvent the pathogens ability to develop resistance. Mannanoligosaccharides bind to type-1 fimbriae, i.e. mannose-sensitive lectins on the membranes of pathogenic microorganisms such as Escherichia coli or Salmonella. Blocking of adhesins on pathogenic cells prevents their binding and spreading on the intestinal wall, and initiating of an enteric infection. The neutralized pathogens are excreted from the digestive tract in faeces (Doeschate and Kenyon, 1999)
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