Abstract
In this study, we prepare and evaluate a novel cellbased micro-platform (microrobot) for active tumor therapy. The microrobots are fabricated utilizing the engulfment activity of immune cells (macrophages) with drug-loaded magnetic liposomes via phagocytosis. First, we synthesize magnetic nanoparticles (MNP) with superparamagnetic properties and high energy absorbance to near-infrared (NIR) light, and load the MNPs to liposomes (MNP-DLs). Then, we prepare the microrobots by incubating the MNP-DLs with the macrophages. After that, we characterize the tumor targeting ability of the microrobots using electromagnetic actuating (EMA) system and a transwell chemotactic assay. Experiment results show that the microrobots can be controlled by an external magnetic field to reach the average velocity of approximately 11 μm/second, and they can cross the membranes mimicking the blood barrier to tumor chemo-attractants with the infiltration rate up to 74%. Therefore, the study proposes an innovative approach for active tumor targeting and NIR light triggered drug delivery using the developed cellular microrobots.
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