Abstract
Recently we have developed a simple and sensitive assay for the measurement of GABA in fluids and tissues by high performance liquid chromatography [16]. The only sample preparation required is deproteinization and usually 100 μl of CSF is all that is required for a reliable determination of OABA. We have measured GABA CSF levels in patients with various neurological disorders as well as in a few control specimens. The control values, around 300 nM, agree with published results. Patients with Parkinson's disease or Huntington's chorea had CSF GABA levels ranging from 26–150 nM with occasional high values and are in general agreement with those reported by Enna et al. [7]. Cerebrospinal fluid GABA levels in patients with myoclonus, stroke, dystonia and other miscellaneous neurological disorders ranged from 50–600 nM, without any recognizable pattern. From the results obtained thus far, low levels of CSF GABA are not necessarily limited to patients with Huntington's chorea or Parkinson's disease.
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