Abstract
The clinical manifestations and needle biopsy findings in eighty-one patients with proved metastatic tumor of the liver have been reviewed. Attention is drawn to a number of insufficiently emphasized features of the disease that may be misleading. These include a characteristic type of hepatic pain, fever, signs of portal hypertension, fluid retention and the presence of a friction rub over the liver. Evidence is presented to show that once signs or symptoms of hepatic metastases appear, the disease is in an advanced stage of development, and that this accounts for the remarkable frequency with which the presence of tumor can be demonstrated by random sampling of the liver with a small biopsy needle. The results of the present study confirm previous reports indicating the great diagnostic value of needle biopsy in metastatic disease of the liver, and support the view that the presence of hepatic metastases does not enhance the hazards of the procedure.
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