Manifestations of epidemic process of tuberculosis among HIV-infected patients and dependence of infection frequency on immunodeficiency level and HIV viral load

Abstract

Objective. To assess the manifestations of the epidemic process of tuberculosis (TB) in HIV-infected persons and the frequency of infection depending on the level of immunodeficiency and viral load.
 Materials and methods. The epidemiological manifestations of TB incidence among HIV-infected and HIV-negative population of the Perm Region for 20142019 were studied. The frequency of TB in HIV-infected patients was determined depending on the level of immunodeficiency (96 patients) and viral load (61 patients).
 Results. On average, the incidence of TB among HIV-infected persons was by 36 times higher than that of noninfected persons. Among those infected and noninfected with HIV, TB was registered significantly more often among adults, and mainly men. The incidence of TB among HIV-infected persons is higher among urban population, while HIV-negative among rural residents. The incidence of TB in HIV-infected persons increases with an increase in the immunodeficiency and viral load.
 Conclusions. Persons with HIV infection are at risk for TB. The incidence of TB in HIV-infected persons increases with an increase in immunodeficiency and viral load.