Abstract
Bone and joint pain in patients with acute lymphocytic leukemia Bone and joint signs and symptoms were retrospectively studied in 70 consecutive patients under 15 years of age with acute lyrnphocytic leukemia. Bone and or joint symptoms, mainly pain, were recorded among 37.5% of patients. Bone or joint pain were the primary cause of consultation in 1 1.4% of the whole cases, they were an accompanying, even though severe, spontaneously refered symptom in 12.9% cf patients and a mild event in another 11.4% of affected children. The early hemaiological findings were nearly normal in the first subgroup of patients and this accounted for initial mistaken and delayed diagnosis, which included rheumatic, orthopedic and even psychiatric conditions. In the other two subgroups there were no diagnostic errors in the first approach. Osseous and articular findings did not modify prognosis, because there were not significant differences in survival rates among patients with or without bone and or joint pain. Unexplained bone or joint pain together with minor hema;olocical abnormalities should prompt differential diagnosis with acute leukemia.
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