Mangiferin Alleviates Ovalbumin-Induced Allergic Rhinitis via Nrf2/HO-1/NF-κB Signaling Pathways.

Chun Hua Piao,Chang Ho Song,Yan Jing Fan,Ok Hee Chai,Thi Van Nguyen

doi:10.3390/ijms21103415

Chun Hua Piao, Chang Ho Song + Show 3 more

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https://doi.org/10.3390/ijms21103415

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Abstract

Mangiferin (MF), extracted from mango trees, is considered to have anti-inflammatory, anti-apoptotic, and antioxidant effects. However, its effects on allergic rhinitis (AR), remain unclear. We investigated the mechanisms underlying the protective action of MF in ovalbumin (OVA)-induced AR models. AR was induced by OVA challenge in BALB/c mice. Prior to this, MF and dexamethasone were administered. Mice were examined for nasal mucosal inflammation, the generation of allergen-specific cytokine response, and histopathological changes in the nasal mucosa and lung tissue. MF ameliorated nasal symptoms and nasal mucosa inflammation in OVA-induced AR and reduced inflammatory cell infiltration and epithelial disruption in these tissues. MF inhibited the overproduction of Th2/Th17 cytokines and transcription factors. MF downregulated the HO-1/Nrf2 pathways, reduced oxidative stress biomarker levels, and the NF-κB signaling pathways were inhibited. MF exerts protective effects in AR by inhibiting NF-κB and activating HO-1/Nrf2 pathways. MF could be used for the treatment of AR.

Highlights

Allergic rhinitis (AR) is an IgE-mediated inflammatory disease in the nasal mucosa, characterized by infiltration and activation of inflammatory cells such as mast cells and eosinophils [1]
These results indicated that MF plays a therapeutic role in allergic rhinitis (AR)
Our results showed that MF treatment could inhibit the production and secretion of OVA-specific immunoglobulins in serum and allergic cytokines like IL-4, IL -5, IL -6, IL-13, IL-17, TNF-α and NF-κB activation in nasal lavage fluid (NALF) caused by OVA induction

Summary

Introduction

Allergic rhinitis (AR) is an IgE-mediated inflammatory disease in the nasal mucosa, characterized by infiltration and activation of inflammatory cells such as mast cells and eosinophils [1]. Researchers have found many natural compounds that have antioxidant and anti-inflammatory activities [4]. Mangiferin (1,3,6,7-Tetrahydroxyxanthone C2-β-d-glucoside, MF) is thought to prevent organ damage arising from different causes, and it has anti-inflammatory, anti-apoptotic, and antioxidant effects [5]. It has been reported to affect the activation or expression of several signaling cascades such as NF-κB, Nrf2/HO-1, mitochondrial-dependent pathways, and to target several cytokines, interleukin (IL)-6, and antioxidant enzymes, such as superoxide dismutase (SOD) and catalase (CAT) [5,6,7,8]. The interaction between Nrf and NF-κB is interesting because numerous phytochemicals that have anti-inflammatory, anti-oxidative, or anti-cancer properties suppress NF-κB signaling and activate the Nrf pathway [11]

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