Abstract
Manganese(III) acetate [Mn(OAc)3]-mediated free-radical reactions have emerged as important synthetic methods. Manganese acetate can be used as an oxidizing and chlorinating agent[ 1 ] and in some cases in alkylations[ 1 ] and inter- and intramolecular cyclizations.[ 2 ] Due to the poor solubility of Mn(OAc)3 in common organic solvents, Mn(OAc)3-mediated reactions are often carried out in acetic acid, although other solvents including toluene, alcohols, acetonitrile, dichloromethane and chlorobenzene can be used.[ 3 ] Mn(OAc)3 promotes the synthesis of many alkaloids,[ 4 ] triterpenes,[ 5 ] and drugs.[ 6 ] Mn(OAc)3 is commercially available in form of its dehydrate as a brown powder and can be prepared in the laboratory[ 7 ] by adding KMnO4 to a pre-heated mixture of Mn(OAc)2 and glacial acetic acid (Scheme [1]). Addition of acetic anhydride to the reaction produces the anhydrous form.[ 8 ]
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