Abstract
Conjugated polymer nanoparticles (CPNs) possess many useful and fascinating properties, including high brightness, excellent photostability, good water-dispersibility, low cytotoxicity, and easy functionalization, showing promising application in bioimaging. In this work, one kind of optical/magnetic conjugated polyelectrolyte has been designed and synthesized by introducing Mn(III) porphyrin (T1-weighted relaxivity) into a fluorescent fluorene based polymer backbone. Fluorescent/magnetic conjugated polymer nanoparticles (FM-CPNs) were prepared by self-assembly in the phosphate buffer solution caused by their amphiphilic structures with hydrophobic backbones and hydrophilic side chains. Their photophysical properties have been investigated in details via UV–vis absorption and fluorescent emission spectra. Investigation of its magnetic properties has shown that the FM-CPNs exhibit high T1-weighted relaxivity value, making them promising candidates for T1-enhanced magnetic resonance imaging agent. Further cell imaging has been realized successfully using FM-CPNs as staining label, and cytotoxicity was evaluated by the methyl thiazolyl tetrazolium (MTT) assay.
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