Abstract
This study aimed to explore the optimal dose and manner of administration for visualization of the auditory pathway on manganese-enhanced MRI (MEMRI). Twenty-four healthy male Sprague-Dawley rats were randomly divided into three experimental groups (n=8 for Groups A, B and C). The rats in Groups A, B and C were subjected to MnCl2 injection through the tympanum, inner ear endolymph and perilymph, respectively (0.2M for four rats and 0.4M for the others in each group) and observed at 1, 2, 3, 4, 7 and 10days after the operation with 3.0T MRI. The signal intensity (SI) and dynamic changes of the auditory pathways at various times, and at two doses through three injection routes, were compared by statistical analysis. Administration of MnCl2 through the perilymph best showed the complete auditory pathway (P<0.01), whereas administration though the tympanum only demonstrated part of the pathway. The SI was highest at 24h after administration of the tracer and began to decline at 48h. The SI of the auditory cortex was higher after the injection of 0.4M MnCl2 than that of 0.2M MnCl2 . MEMRI best demonstrated the whole auditory pathway at 24h after the injection of 0.4M MnCl2 through the perilymph in the rat, which provided an optimal method for the study of MEMRI of the auditory pathway in the animal model.
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